89 citations · 89 across the 4 of their papers we have counts for
4 papers
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Duncan K Ralph, Athanasios G Bakis, Jared Galloway +6
B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (G…
Bayesian inference of antibody evolutionary dynamics using multitype branching processes
Athanasios G. Bakis, Ashni A. Vora, Tatsuya Araki +8
When our immune system encounters foreign antigens (i.e., from pathogens), the B cells that produce our antibodies undergo a cyclic process of proliferation, mutation, and selectio…
On Possible Indicators of Negative Selection in Germinal Centers
Bertrand Ottino-Loffler, Gabriel Victora
A central feature of vertebrate immune response is affinity maturation, wherein antibody-producing B cells undergo evolutionary selection in microanatomical structures called germi…
Using genotype abundance to improve phylogenetic inference
William S. DeWitt, Luka Mesin, Gabriel D. Victora +2
Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times. This motivates strate…