4 papers
GTPO and GRPO-S: Token and Sequence-Level Reward Shaping with Policy Entropy
Hongze Tan, Zihan Wang, Jianfei Pan +7
Reinforcement Learning (RL) is pivotal for enhancing Large Language Model (LLM) reasoning, yet mainstream algorithms such as GRPO and DAPO remain constrained by a coarse-grained cr…
Multimodal 3D Genome Pre-training
Minghao Yang, Pengteng Li, Yan Liang +6
Deep learning techniques have driven significant progress in various analytical tasks within 3D genomics in computational biology. However, a holistic understanding of 3D genomics…
HiCMamba: Enhancing Hi-C Resolution and Identifying 3D Genome Structures with State Space Modeling
Minghao Yang, Zhi-An Huang, Zhihang Zheng +5
Hi-C technology measures genome-wide interaction frequencies, providing a powerful tool for studying the 3D genomic structure within the nucleus. However, high sequencing costs and…
Rene: A Pre-trained Multi-modal Architecture for Auscultation of Respiratory Diseases
Pengfei Zhang, Zhihang Zheng, Shichen Zhang +2
Compared with invasive examinations that require tissue sampling, respiratory sound testing is a non-invasive examination method that is safer and easier for patients to accept. In…