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q-bio.GN2024
FastImpute: A Baseline for Open-source, Reference-Free Genotype Imputation Methods -- A Case Study in PRS313
Aaron Ge, Jeya Balasubramanian, Xueyao Wu +2
Genotype imputation enhances genetic data by predicting missing SNPs using reference haplotype information. Traditional methods leverage linkage disequilibrium (LD) to infer untype…
q-bio.GN2023
mSigSDK -- private, at scale, computation of mutation signatures
Aaron Ge, Yasmmin Côrtes Martins, Tongwu Zhang +5
In our previous work, we demonstrated that it is feasible to perform analysis on mutation signature data without the need for downloads or installations and analyze individual pati…
q-bio.GN2023
A FAIR platform for reproducing mutational signature detection on tumor sequencing data
Aaron Ge, Tongwu Zhang, Clara Bodelon +3
This paper presents a portable, privacy-preserving, in-browser platform for the reproducible assessment of mutational signature detection methods from sparse sequencing data genera…