3 papers
q-bio.BM2026
Dark energy: the cost of function in protein evolution
Ezequiel A. Galpern, Federico Caamaño, Ignacio E. Sánchez +1
The evolutionary fate of proteins is driven by both folding stability and biological function, dual constraints that often conflict, creating frustration and imposing functional co…
q-bio.BM2025
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
q-bio.BM2023
Solvent constraints for biopolymer folding and evolution in extraterrestrial environments
Ignacio E. Sánchez, Ezequiel A. Galpern, Diego U. Ferreiro
We propose that spontaneous folding and molecular evolution of biopolymers are two universal aspects that must concur for life to happen. These aspects are fundamentally related to…