2 papers
q-bio.BM2025
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
q-bio.BM2024
Reassessing the Exon-Foldon correspondence using Frustration Analysis
Ezequiel A. Galpern, Hana Jaafari, Carlos Bueno +2
Protein folding and evolution are intimately linked phenomena. Here, we revisit the concept of exons as potential protein folding modules across 38 abundant and conserved protein f…