39 citations · 88 across the 10 of their papers we have counts for
4 papers · 1 filter
From Cancer Drivers to Cancer Keepers: Paradigm Shift and Clinical Implications
Xizhe Zhang, Weixiong Zhang
Cancer research has traditionally focused on identifying driver genes, those with mutations that initiate tumorigenesis. The Cancer Driver Gene (CDG) paradigm, further supported by…
NetMoST: A network-based machine learning approach for subtyping schizophrenia using polygenic SNP allele biomarkers
Xinru Wei, Shuai Dong, Zhao Su +7
Subtyping neuropsychiatric disorders like schizophrenia is essential for improving the diagnosis and treatment of complex diseases. Subtyping schizophrenia is challenging because i…
Identification of cancer-keeping genes as therapeutic targets by finding network control hubs
Xizhe Zhang, Chunyu Pan, Xinru Wei +9
Finding cancer driver genes has been a focal theme of cancer research and clinical studies. One of the recent approaches is based on network structural controllability that focuses…
Total controllability analysis discovers explainable drugs for Covid-19 treatment
Xinru Wei, Chunyu Pan, Xizhe Zhang +1
Network medicine has been pursued for Covid-19 drug repurposing. One such approach adopts structural controllability, a theory for controlling a network (the cell). Motivated to pr…