4 papers
Extraordinary stiffening and reciprocal control in a DNA condensate/actin composite
Sam Wilken, Austin Hopkins, Kyu Hwan Choi +6
Soft composites, materials consisting of inclusions within a polymeric matrix, offer a broad design space with diverse mechanical properties. Composite stiffness is normally set by…
Diverse, Distinct, and Densely Packed DNA Droplets
Aria S. Chaderjian, Sam Wilken, Omar A. Saleh
The liquid-liquid phase separation of biomolecules is an important process for intracellular organization. Biomolecular sequence combinatorics leads to a large variety of proteins…
Condensation and activator/repressor control of a transcription-regulated biomolecular liquid
Sam Wilken, Gabrielle R. Abraham, Omar A. Saleh
Cells operate in part by compartmentalizing chemical reactions. For example, recent work has shown that chromatin, the material that contains the cell's genome, can auto-regulate i…
Controlling the size and adhesion of DNA droplets using surface-active DNA molecules
Daqian Gao, Sam Wilken, Anna Nguyen +3
Liquid droplets of biomolecules serve as organizers of the cellular interior and are of interest in biosensing and biomaterials applications. Here, we investigate means to tune the…