most citedLocally D-optimal designs based on a class of composed models resulted from blending Emax and one-compartment models

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stat.ME2008★ 23 cited

Locally D-optimal designs based on a class of composed models resulted from blending Emax and one-compartment models

X. Fang, A. S. Hedayat

A class of nonlinear models combining a pharmacokinetic compartmental model and a pharmacodynamic Emax model is introduced. The locally D-optimal (LD) design for a four-parameter c…