3 papers
physics.med-ph2025
Unraveling the Redox Mechanisms Underlying FLASH Radiotherapy: Critical Dose Thresholds and NRF2-Driven Tissue Sparing
Yan Zhang, Chenyang Huang, Ankang Hu +10
FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional dose-rate irradiation (CONV-RT) while significantly reducing radiation damage to normal tissues. How…
physics.med-ph2025
Correlation Between DNA Double-Strand Break Distribution in 3D Genome and Radiation-Induced Cell Death
Ankang Hu, Wanyi Zhou, Xiyu Luo +2
The target theory is the most classical hypothesis explaining radiation-induced cell death, the physical or biological nature of the "target" remains ambiguous. This study hypothes…
physics.med-ph2024
Influencing Factors of the FLASH Effect: Unveiling the Importance of Free Radicals
Yan Zhang, Chenyang Huang, Ankang Hu +10
Purpose: Our aim was to elucidate the critical factors responsible for inducing the FLASH effect, focusing on the role of free radicals through simulation and experimental approach…