7 citations · 11 across the 7 of their papers we have counts for
8 papers
ViraHinter: a dual-modal artificial intelligence framework for predicting virus-host interactions
Weiqiang Bai, Fei Wang, Jialin Wang +10
Protein-protein interactions (PPIs) between a virus and its host govern infection, replication, and pathogenesis. While high-throughput mapping has identified thousands of virus-ho…
Inference-Time Alignment Control for Diffusion Models with Reinforcement Learning Guidance
Luozhijie Jin, Zijie Qiu, Jie Liu +5
Denoising-based generative models, particularly diffusion and flow matching algorithms, have achieved remarkable success. However, aligning their output distributions with complex…
Fitness aligned structural modeling enables scalable virtual screening with AuroBind
Zhongyue Zhang, Jiahua Rao, Jie Zhong +22
Most human proteins remain undrugged, over 96% of human proteins remain unexploited by approved therapeutics. While structure-based virtual screening promises to expand the druggab…
Model Decides How to Tokenize: Adaptive DNA Sequence Tokenization with MxDNA
Lifeng Qiao, Peng Ye, Yuchen Ren +5
Foundation models have made significant strides in understanding the genomic language of DNA sequences. However, previous models typically adopt the tokenization methods designed f…
COMET: Benchmark for Comprehensive Biological Multi-omics Evaluation Tasks and Language Models
Yuchen Ren, Wenwei Han, Qianyuan Zhang +13
As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although res…
LayerMatch: Do Pseudo-labels Benefit All Layers?
Chaoqi Liang, Guanglei Yang, Lifeng Qiao +4
Deep neural networks have achieved remarkable performance across various tasks when supplied with large-scale labeled data. However, the collection of labeled data can be time-cons…
BEACON: Benchmark for Comprehensive RNA Tasks and Language Models
Yuchen Ren, Zhiyuan Chen, Lifeng Qiao +10
RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms. Despite the emerg…
Toward Understanding BERT-Like Pre-Training for DNA Foundation Models
Chaoqi Liang, Lifeng Qiao, Peng Ye +9
With the success of large-scale pre-training in language tasks, there is an increasing trend of applying it to the domain of life sciences. In particular, pre-training methods base…