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stat.ME2026
Qualify-Then-Borrow: A Five-Step Framework for Bayesian Borrowing Beyond Outcome Agreement
Haitao Pan
PURPOSE: Dynamic Bayesian borrowing methods adapt the contribution of external information according to agreement or disagreement with current data. Qualify-Then-Borrow (QTB) makes…
stat.ME2026
Interim Monitoring as an Information-Time Alignment Problem: The WCR Framework for Time-to-Event Trials
Haitao Pan, Zhongheng Cai
Interim monitoring in time-to-event trials must balance inferential maturity with operationally meaningful timing. Event-driven designs align analyses with event accumulation but c…
stat.ME2025
A Bayesian Optimal Phase II Design for Randomized Immunotherapy Trials with Delayed Treatment Effects
Zhongheng Cai, Haitao Pan
Immunotherapy has transformed cancer treatment, yet its delayed therapeutic effects often lead to non-proportional hazards, rendering many conventional phase II designs underpowere…