4 papers
How many mutations does it take to evolve a new function?
Nida Farheen, Zachary Boroda, Ethan Levien +1
Biochemical and genetic networks in cells evolve to produce new functions. Evolution is guided by the genotype to phenotype map which describes how mutations at the molecular scale…
The Trajectory Statistics of Biological Exploratory Dynamics
Sara D. Mahdavi, Gabriel L. Salmon, Minakshi Ashok +4
Biological processes, from molecules diffusing to their regulatory destinations to whales pursuing food or mates, are widely exploratory. Such behaviors are effective when some ver…
What do the fundamental constants of physics tell us about life?
Pankaj Mehta, Jane Kondev
In the 1970s, the renowned physicist Victor Weisskopf famously developed a research program to qualitatively explain properties of matter in terms of the fundamental constants of p…
Biological Processes as Exploratory Dynamics
Jane Kondev, Marc Kirschner, Hernan G. Garcia +2
Many biological processes can be thought of as the result of an underlying dynamics in which the system repeatedly undergoes distinct and abortive trajectories with the dynamical p…