5 papers
Hysteresis and multistability in network spreading with neuronal activity feedback
Christoffer G. Alexandersen, Dani S. Bassett
Spreading processes on networks often interact with other dynamics on the same nodes. Neurodegenerative disease provides one example: pathological proteins spread through anatomica…
Activity-dependent epidemic spreading on multiscale brain networks predicts Alzheimer's disease progression
Christoffer G. Alexandersen, Suman S. Kulkarni, Jessica T. Davis +3
Neurodegenerative diseases can be viewed as spreading processes on brain networks, in which pathological proteins propagate between anatomically connected brain regions. Mathematic…
QUIET: Quantifying Underutilized Influential Edges for Targeted Synchronization
Sovesh Mohapatra, Christoffer G. Alexandersen, Panagiotis Fotiadis +4
Network control theory can be used to model intrinsic and extrinsic strategies to steer neural dynamics. Standard approaches are node-centric, structural, and focused on achieving…
Network Models of Neurodegeneration: Bridging Neuronal Dynamics and Disease Progression
Christoffer G. Alexandersen, Georgia S. Brennan, Julia K. Brynildsen +3
Neurodegenerative diseases are characterized by the accumulation of misfolded proteins and widespread disruptions in brain function. Computational modeling has advanced our underst…
HeMiTo-dynamics: a characterisation of mammalian prion toxicity using non-dimensionalisation, linear stability and perturbation analyses
Johannes G. Borgqvist, Christoffer Gretarsson Alexandersen
Prion-like proteins play crucial parts in biological processes in organisms ranging from yeast to humans. For instance, many neurodegenerative diseases are believed to be caused by…