3 papers
math.OC2026
Gradient flow for finding E-optimal designs
Jieling Shi, Kim-Chuan Toh, Xin T. Tong +1
The -optimality criterion for a regression model maximizes the smallest eigenvalue of the information matrix and becomes non-differentiable when this eigenvalue has multiplicity…
stat.ME2025
LORDs: Locally Optimal Restricted Designs for Phase I/II Dose-Finding Studies
Oleksandr Sverdlov, Yevgen Ryeznik, Weng Kee Wong
We propose Locally Optimal Restricted Designs (LORDs) for phase I/II dose-finding studies that focus on both efficacy and toxicity outcomes. As an illustrative application, we find…
stat.ME2025
Single and multi-objective optimal designs for group testing experiments with a focus on screening for an infectious disease
Chi-Kuang Yeh, Weng Kee Wong, Julie Zhou
Group testing techniques are widely used in resource-constrained settings, such as infectious-disease screening, blood safety, DNA library screening, and industrial inspection, whe…