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stat.ME2025
LORDs: Locally Optimal Restricted Designs for Phase I/II Dose-Finding Studies
Oleksandr Sverdlov, Yevgen Ryeznik, Weng Kee Wong
We propose Locally Optimal Restricted Designs (LORDs) for phase I/II dose-finding studies that focus on both efficacy and toxicity outcomes. As an illustrative application, we find…
stat.ME2024★ 1 cited
Incertus.jl -- The Julia Lego Blocks for Randomized Clinical Trial Designs
Yevgen Ryeznik, Oleksandr Sverdlov
In this paper, we present Insertus.jl, the Julia package that can help the user generate a randomization sequence of a given length for a multi-arm trial with a pre-specified targe…