3 papers
cs.LG2025
A Unification of Discrete, Gaussian, and Simplicial Diffusion
Nuria Alina Chandra, Yucen Lily Li, Alan N. Amin +5
To model discrete sequences such as DNA, proteins, and language using diffusion, practitioners must choose between three major methods: diffusion in discrete space, Gaussian diffus…
cs.LG2025
Is Sequence Information All You Need for Bayesian Optimization of Antibodies?
Sebastian W. Ober, Calvin McCarter, Aniruddh Raghu +4
Bayesian optimization is a natural candidate for the engineering of antibody therapeutic properties, which is often iterative and expensive. However, finding the optimal choice of…
cs.LG2025
Guided Sequence-Structure Generative Modeling for Iterative Antibody Optimization
Aniruddh Raghu, Sebastian Ober, Maxwell Kazman +1
Therapeutic antibody candidates often require extensive engineering to improve key functional and developability properties before clinical development. This can be achieved throug…