3 papers
q-bio.PE2026
Mutation Order and Selection Shape Intratumor Heterogeneity in Tumor Evolution
Yichen Chu, Xiaoxia Sheng, Xuanming Zhang +1
Cancer progression often requires multiple driver mutations, but the same drivers may be acquired in different orders. How these pathways jointly shape tumor clonal structure remai…
math.PR2025
Parameter Estimation in Recurrent Tumor Evolution with Finite Carrying Capacity
Kevin Leder, Zicheng Wang, Xuanming Zhang
In this work, we investigate the population dynamics of tumor cells under therapeutic pressure. Although drug treatment initially induces a reduction in tumor burden, treatment fai…
stat.AP2024
Parameter Estimation from Single Patient, Single Time-Point Sequencing Data of Recurrent Tumors
Kevin Leder, Ruping Sun, Zicheng Wang +1
In this study, we develop consistent estimators for key parameters that govern the dynamics of tumor cell populations when subjected to pharmacological treatments. While these trea…