3 papers
cs.LG2025
Bidirectional Representations Augmented Autoregressive Biological Sequence Generation
Xiang Zhang, Jiaqi Wei, Zijie Qiu +5
Autoregressive (AR) models, common in sequence generation, are limited in many biological tasks such as de novo peptide sequencing and protein modeling by their unidirectional natu…
cs.LG2025
Universal Biological Sequence Reranking for Improved De Novo Peptide Sequencing
Zijie Qiu, Jiaqi Wei, Xiang Zhang +6
De novo peptide sequencing is a critical task in proteomics. However, the performance of current deep learning-based methods is limited by the inherent complexity of mass spectrome…
q-bio.QM2023
ContraNovo: A Contrastive Learning Approach to Enhance De Novo Peptide Sequencing
Zhi Jin, Sheng Xu, Xiang Zhang +6
De novo peptide sequencing from mass spectrometry (MS) data is a critical task in proteomics research. Traditional de novo algorithms have encountered a bottleneck in accuracy due…