14 papers
MolBioKG: Grounding Out-of-Graph Molecules in Biomedical Knowledge Graphs via Multi-Resolution Structural Anchoring
Yiming Zhang, Hikaru Shindo, Shuan Chen +5
Biomedical knowledge graphs (KGs) accelerate drug discovery, but standard pipelines assume query molecules already exist as graph entities, leaving unregistered molecules disconnec…
Pepti-drift: Toxicity-Repulsive Drifting for Antigen-Conditioned Discrete Peptide Generation
Takashi Fujiwara, Hikaru Shindo, Kaushalya Madhawa +2
Peptides are a promising therapeutic modality that combine the chemical tunability of small molecules with the target specificity of macromolecular therapeutics. However, designing…
Learning Explicit Behavioral Models with Adaptive Questions and World-Model Probes
Hikaru Shindo, Yu Deng, Teng Cao +5
Interactive agents trained only against task return can achieve high scores while failing to represent the mechanisms that make their actions succeed. This makes brittle behavior d…
STORM: Segment, Track, and Object Re-Localization from a Single Image
Yu Deng, Teng Cao, Hikaru Shindo +3
Accurate 6D pose estimation and tracking are core capabilities for physical AI systems, yet real-world deployment remains brittle and labor-intensive. Many pipelines rely on CAD mo…
ActivationReasoning: Logical Reasoning in Latent Activation Spaces
Lukas Helff, Ruben Härle, Wolfgang Stammer +6
Large language models (LLMs) excel at generating fluent text, but their internal reasoning remains opaque and difficult to control. Sparse autoencoders (SAEs) make hidden activatio…
Kintsugi: Learning Policies by Repairing Executable Knowledge Bases
Teng Cao, Yu Deng, Hikaru Shindo +6
Modern embodied agents achieve impressive performance, but their task knowledge is often stored in neural weights, latent state, or prompt-bound memory, making individual policy kn…