27 citations · 29 across the 13 of their papers we have counts for
14 papers
Single-Pass Decision Scores Enable Rapid Classification with Adjustable Thresholds in Medical Multimodal Large Language Models
Patrick Wienholt, Frederik Hauke, Christiane Kuhl +3
Multimodal large language models (MLLMs) answer binary clinical questions with a yes or no token, leaving the decision threshold implicit and fixed. We derive a continuous score fr…
Foundation-model-guided radiogenomic discovery linking cancer genomes to cancer scans
Frederik Hauke, Jeremias Krause, Patrick Wienholt +6
The function of many genes is still unknown, and conventional driver-discovery methods, which rely on how frequently a gene is mutated, cannot assess genes that are only rarely aff…
Bayesian uncertainty estimation improves clinical decision making in medical AI agents
Frederik Hauke, Patrick Wienholt, Christiane Kuhl +4
Machine learning models for medical image analysis typically lack a reliable measure of confidence, limiting their use in ambiguous or atypical cases. Here we show that Monte Carlo…
The pretraining domain outweighs the training objective in setting the privacy-utility trade-off of differentially private medical image analysis
Soroosh Tayebi Arasteh, Mina Farajiamiri, Mahshad Lotfinia +7
Differential privacy limits how much each training image can influence a medical imaging model but lowers its diagnostic accuracy. Pretrained weights reduce this loss. It is unknow…
Effect of Reporting Mode and Clinical Experience on Radiologists' Gaze and Image Analysis Behavior in Chest Radiography
Mahta Khoobi, Marc Sebastian von der Stueck, Felix Barajas Ordonez +11
Structured reporting (SR) and artificial intelligence (AI) may transform how radiologists interact with imaging studies. This prospective study (July to December 2024) evaluated th…
Large Language Model-Based Uncertainty-Adjusted Label Extraction for Artificial Intelligence Model Development in Upper Extremity Radiography
Hanna Kreutzer, Anne-Sophie Caselitz, Thomas Dratsch +4
Objectives: To evaluate GPT-4o's ability to extract diagnostic labels (with uncertainty) from free-text radiology reports and to test how these labels affect multi-label image clas…
Hallucination Filtering in Radiology Vision-Language Models Using Discrete Semantic Entropy
Patrick Wienholt, Sophie Caselitz, Robert Siepmann +6
To determine whether using discrete semantic entropy (DSE) to reject questions likely to generate hallucinations can improve the accuracy of black-box vision-language models (VLMs)…
Resolution scaling governs DINOv3 transfer performance in chest radiograph classification
Soroosh Tayebi Arasteh, Mina Shaigan, Christiane Kuhl +3
Self-supervised learning (SSL) has improved visual representation learning, but its value in chest radiography remains uncertain. DINOv3 extends earlier SSL models through Gram-anc…
MedicalPatchNet: A Patch-Based Self-Explainable AI Architecture for Chest X-ray Classification
Patrick Wienholt, Christiane Kuhl, Jakob Nikolas Kather +2
Deep neural networks excel in radiological image classification but frequently suffer from poor interpretability, limiting clinical acceptance. We present MedicalPatchNet, an inher…
T2 Radiomic Features Are More Sensitive Than Mean T2 for Cartilage Load Response: A Stress MRI Study
Teresa Lemainque, Philipp Schad, Simon Westfechtel +6
Objective: To assess response-to-loading in a human cadaveric knee joint model under different loading conditions before and after meniscectomy Design: In this prospective study, s…
Diagnostic Accuracy of Open-Source Vision-Language Models on Diverse Medical Imaging Tasks
Gustav Müller-Franzes, Debora Jutz, Jakob Nikolas Kather +3
This retrospective study evaluated five VLMs (Qwen2.5, Phi-4, Gemma3, Llama3.2, and Mistral3.1) using the MedFMC dataset. This dataset includes 22,349 images from 7,461 patients en…
A European Multi-Center Breast Cancer MRI Dataset
Gustav Müller-Franzes, Lorena Escudero Sánchez, Nicholas Payne +18
Early detection of breast cancer is critical for improving patient outcomes. While mammography remains the primary screening modality, magnetic resonance imaging (MRI) is increasin…
RadioRAG: Online Retrieval-augmented Generation for Radiology Question Answering
Soroosh Tayebi Arasteh, Mahshad Lotfinia, Keno Bressem +7
Large language models (LLMs) often generate outdated or inaccurate information based on static training datasets. Retrieval-augmented generation (RAG) mitigates this by integrating…
An Ordinal Regression Framework for a Deep Learning Based Severity Assessment for Chest Radiographs
Patrick Wienholt, Alexander Hermans, Firas Khader +5
This study investigates the application of ordinal regression methods for categorizing disease severity in chest radiographs. We propose a framework that divides the ordinal regres…