2 papers
cs.CE2025
LSMTCR: A Scalable Multi-Architecture Model for Epitope-Specific T Cell Receptor de novo Design
Ruihao Zhang, Xiao Liu
Designing full-length, epitope-specific TCR α\b{eta} remains challenging due to vast sequence space, data biases and incomplete modeling of immunogenetic constraints. We present LS…
cs.LG2025
Classification of autoimmune diseases from Peripheral blood TCR repertoires by multimodal multi-instance learning
Ruihao Zhang, Mao chen, Fei Ye +3
T cell receptor (TCR) repertoires encode critical immunological signatures for autoimmune diseases, yet their clinical application remains limited by sequence sparsity and low witn…