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q-bio.BM2026
Ligand-Conditioned Discrete Diffusion for Protein Sequence-Structure Co-Design
Chen Wei, Fanding Xu, Minghao Sun +5
Proteins perform their biological functions through three-dimensional structures encoded by amino acid sequences, and ligand-binding protein co-design requires models that generate…
q-bio.BM2025
RiboPO: Preference Optimization for Structure- and Stability-Aware RNA Design
Minghao Sun, Hanqun Cao, Zhou Zhang +10
Designing RNA sequences that reliably adopt specified three-dimensional structures while maintaining thermodynamic stability remains challenging for synthetic biology and therapeut…