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q-bio.BM2026
Ligand-Conditioned Discrete Diffusion for Protein Sequence-Structure Co-Design
Chen Wei, Fanding Xu, Minghao Sun +5
Proteins perform their biological functions through three-dimensional structures encoded by amino acid sequences, and ligand-binding protein co-design requires models that generate…
q-bio.BM2025
EnzyControl: Adding Functional and Substrate-Specific Control for Enzyme Backbone Generation
Chao Song, Zhiyuan Liu, Han Huang +6
Designing enzyme backbones with substrate-specific functionality is a critical challenge in computational protein engineering. Current generative models excel in protein design but…