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Lead-Time Simple Exponential Smoothing as a Configurable, Uncertainty-Aware Framework for Adaptive Radiotherapy Monitoring
Robert Boyd, Wolfgang A. Tomé
Lead-time simple exponential smoothing (LT-SES) is developed as a configurable, uncertainty-aware framework for adaptive radiotherapy monitoring, in which a prospectively selected…
A primer on treatment planning aspects for temporally modulated pulsed radiation therapy
Christian Velten, Adam Bayliss, Jiayi Huang +1
Temporally modulated pulsed radiotherapy (TMPRT) delivers conventional fraction doses of radiation using temporally separated pulses of low doses (<30 cGy) yielding fraction-effect…
Radiosensitization beyond DNA damage: Monte Carlo simulations of realistic nanomaterial biodistributions
Christian Velten, Brett Bell, Wolfgang A. Tomé
We investigated cellular distribution of a tumor-specific gadolinium chelate in 4T1 and U87 cancer cells with the goal to generate more realistic geometries for Monte Carlo simulat…
Multi-compartmental modeling for Gd-EOB-DTPA using sparse human DCE-MRI data
Christian Velten, Megi Gjini, N. Patrik Brodin +1
Purpose: To derive kinetic equations for multi-compartmental contrast agent distribution from first principles and apply it to two and three compartments for Gd-EOB-DTPA using low…