most citedWhat is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators

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stat.ME2026

Heterogeneous survivor average causal effects beyond monotonicity: Applications to a clinical trial evaluating mechanical ventilation strategies

Zihan Zhu, Guangyu Tong, Fernando Godinho Zampieri +3

Clinical trials in critical care often evaluate outcomes that are truncated by death, such as time to discharge alive, for which treatment effects are not well defined among patien…

stat.ME2026

Saturation in G: simple & robust causal inference in cluster randomized trials with informative cluster sizes

Kenneth M. Lee, Michael O. Harhay, Fan Li

Cluster randomized trials (CRTs) can exhibit informative cluster sizes (ICS) where cluster size is associated with outcomes and/or treatment effects. Under ICS, the individual and…

stat.ME2026

Who's Winning? Clarifying Estimands Based on Win Statistics in Cluster Randomized Trials

Kenneth M. Lee, Xi Fang, Fan Li +1

Treatment effect estimands based on win statistics, including the win ratio, win odds, and win difference are increasingly popular targets for summarizing endpoints in clinical tri…

stat.ME2025

Design-based nested instrumental variable analysis

Zhe Chen, Xinran Li, Michael O. Harhay +1

Two binary instrumental variables (IVs) are nested if individuals who comply under one binary IV also comply under the other. This situation often arises when the two IVs represent…

stat.ME2025

Evaluating Informative Cluster Size in Cluster Randomized Trials

Bryan S. Blette, Zhe Chen, Brennan C. Kahan +3

In cluster randomized trials, the average treatment effect among individuals (i-ATE) can be different from the cluster average treatment effect (c-ATE) when informative cluster siz…

stat.ME2025

Randomization inference for stepped-wedge designs with noncompliance with application to a palliative care pragmatic trial

Jeffrey Zhang, Zhe Chen, Xinyuan Chen +5

While palliative care is increasingly commonly delivered to hospitalized patients with serious illnesses, few studies have estimated its causal effects. Courtright et al. (2016) ad…

stat.ME2025

Principal stratification with recurrent events truncated by a terminal event: A nested Bayesian nonparametric approach

Yuki Ohnishi, Michael O. Harhay, Guangyu Tong +1

Recurrent events often serve as key endpoints in clinical studies but may be prematurely truncated by terminal events such as death, creating selection bias and complicating causal…

stat.ME2025

Bayesian inference for cluster-randomized trials with multivariate outcomes subject to both truncation by death and missingness

Guangyu Tong, Chenxi Li, Eric Velazquez +2

Cluster-randomized trials (CRTs) on fragile populations frequently encounter complex attrition problems where the reasons for missing outcomes can be heterogeneous, with participan…

stat.ME2025★ 1 cited

What is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators

Kenneth M. Lee, Andrew B. Forbes, Jessica Kasza +5

In the analysis of cluster randomized trials (CRTs), previous work has defined two meaningful estimands: the individual-average treatment effect (iATE) and cluster-average treatmen…

stat.ME2025

A Bayesian approach to the survivor average causal effect in cluster-randomized crossover trials

Dane Isenberg, Michael O. Harhay, Andrew B. Forbes +3

In cluster-randomized crossover (CRXO) trials, groups of individuals are randomly assigned to two or more sequences of alternating treatments. Since clusters serve as their own con…