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20242026
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physics.chem-ph2026

CovAngelo: A hybrid quantum-classical computing platform for accurate and scalable drug discovery

Linn Evenseth, Kamil Galewski, Witold Jarnicki +6

We present a computational platform for modeling chemical reactions in complex molecular environments, focused on ligand-protein binding in drug discovery. The platform implements…

physics.chem-ph2025

Atomistic QM/Classical Modeling of Surface-Enhanced Infrared Absorption

Sveva Sodomaco, Piero Lafiosca, Tommaso Giovannini +1

We present a multiscale quantum mechanics/classical (QM/MM) approach for modeling surface-enhanced infrared absorption (SEIRA) spectra of molecules adsorbed on plasmonic nanostruct…

physics.chem-ph2025

Vertical Excitation Energies of Embedded Systems: The Vertical Excitation Model (VEM) within Polarizable QM/MM

Chiara Sepali, Piero Lafiosca, Linda Goletto +2

Polarizable Quantum Mechanics/Molecular Mechanics (QM/MM) approaches based on fluctuating charges and dipoles (QM/FQ(F)) are formulated within the state-specific Vertical Excita…

physics.chem-ph2024

Mixed Atomistic-Implicit Quantum/Classical Approach to Molecular Nanoplasmonics

Pablo Grobas Illobre, Piero Lafiosca, Luca Bonatti +2

A multiscale QM/classical approach is presented, that is able to model the optical properties of complex nanostructures composed of a molecular system adsorbed on metal nanoparticl…

physics.chem-ph2024

Fully Polarizable Multiconfigurational Self-consistent Field/Fluctuating Charge Approach

Chiara Sepali, Linda Goletto, Piero Lafiosca +3

A multiscale model based on the coupling of the multiconfigurational self-consistent field (MCSCF) method and the classical atomistic polarizable Fluctuating Charges (FQ) force fie…