1 citations · 1 across the 4 of their papers we have counts for
4 papers
PerturbCellRL: Aligning Distributions and Grounding Biology via Post-Training Perturbation Generators
Dongxia Wu, Mingyu Li, Yuhui Zhang +4
Single-cell perturbation models can reduce costly wet-lab screening by predicting how cells respond transcriptionally to interventions. Recent advances in flow-matching have enable…
Peptide2Mol: A Diffusion Model for Generating Small Molecules as Peptide Mimics for Targeted Protein Binding
Xinheng He, Yijia Zhang, Haowei Lin +4
Structure-based drug design has seen significant advancements with the integration of artificial intelligence (AI), particularly in the generation of hit and lead compounds. Howeve…
Zero-Shot Cyclic Peptide Design via Composable Geometric Constraints
Dapeng Jiang, Xiangzhe Kong, Jiaqi Han +6
Cyclic peptides, characterized by geometric constraints absent in linear peptides, offer enhanced biochemical properties, presenting new opportunities to address unmet medical need…
Designing Cyclic Peptides via Harmonic SDE with Atom-Bond Modeling
Xiangxin Zhou, Mingyu Li, Yi Xiao +5
Cyclic peptides offer inherent advantages in pharmaceuticals. For example, cyclic peptides are more resistant to enzymatic hydrolysis compared to linear peptides and usually exhibi…