2 citations · 5 across the 11 of their papers we have counts for
11 papers
Assembly Spaces: Formal Definitions and Fast Methods for Approximating Assembly Indices
Gage Siebert, Redwan Chowdhury, Louie Slocombe +1
Assembly theory is an experimental and theoretical framework that introduces a metrological approach to detecting life, with potential applications across diverse substrates. Its t…
Deep-time consistency in proteome elemental composition across cellular and viral life
L. Felipe Benites, Louie Slocombe, Sara I. Walker
Proteins are constructed from a limited alphabet of ~20 amino acids, yet the origins and selection of this specific alphabet are unresolved. One largely overlooked aspect is whethe…
Elemental Stoichiometry as an Ecological Biosignature with Applications to Life Detection
Pilar C. Vergeli, Cole Mathis, John F. Malloy +5
The vast chemical space of possible small molecules, estimated at 10^60 compounds for molecules composed of just C, N, O, and S, is only sparsely occupied by biology. We propose th…
Searching for Life-As-We-Don't-Know-It: Mission-relevant Application of Assembly Theory for Exoplanet Life Detection
Sara Walker, Estelle Janin, Evgenya Shkolnik +2
This white paper introduces a framework for applying Assembly Theory (AT) to planetary atmospheres as a biosignature framework suitable for the Habitable Worlds Observatory (HWO).…
The Physics of Causation
Leroy Cronin, Sara I. Walker
Assembly theory (AT) introduces causation as a material property and establishes a metrology for objects produced by evolution and selection. The physical scale of causation is qua…
A Firefly-inspired Model for Deciphering the Alien
Cameron Brooks, Estelle Janin, Gage Siebert +3
The Search for Extraterrestrial Intelligence (ETI) is, historically, a search for aliens like us, inspired by human centric ideas of intelligence and technology. However, humans ar…
The Emergence of Chirality from Metabolism
John F. Malloy, Camerian Millsaps, Kamesh Narasimhan +4
Molecular chirality is critical to biochemical function, but it is unknown when chiral selectivity first became important in the evolutionary transition from geochemistry to bioche…
Quantifying the Complexity of Materials with Assembly Theory
Keith Y Patarroyo, Abhishek Sharma, Ian Seet +3
Quantifying the evolution and complexity of materials is of importance in many areas of science and engineering, where a central open challenge is developing experimental complexit…
Constructing the Molecular Tree of Life using Assembly Theory and Mass Spectrometry
Amit Kahana, Alasdair MacLeod, Hessam Mehr +5
Here we demonstrate the first biochemistry-agnostic approach to map evolutionary relationships at the molecular scale, allowing the construction of phylogenetic models using mass s…
Experimental Measurement of Assembly Indices are Required to Determine The Threshold for Life
Sara I. Walker, Cole Mathis, Stuart Marshall +1
Assembly Theory (AT) was developed to help distinguish living from non-living systems. The theory is simple as it posits that the amount of selection or Assembly is a function of t…
Assembly Theory and its Relationship with Computational Complexity
Christopher P. Kempes, Michael Lachmann, Andrew Iannaccone +4
Assembly theory (AT) quantifies selection using the assembly equation and identifies complex objects that occur in abundance based on two measurements, assembly index and copy numb…