12 citations · 28 across the 7 of their papers we have counts for
9 papers
Full Three-dimensional Cell Geometry Matters for Epithelial Fluidization
Toshikaze Chiba, Jan Rozman, Matej Krajnc
Epithelial dynamics are often studied using two-dimensional models that omit cell height. Here, we investigate how this third dimension influences tissue fluidization driven by cel…
Active flows drive anchoring of nematics at rigid walls
Michael Fang, Ioannis Hadjifrangiskou, Sumesh P. Thampi +2
Although confinement strongly influences flows in active materials, it remains unclear how active particles align at rigid boundaries when no thermodynamic anchoring is imposed. We…
Why Extensile and Contractile Tissues Could be Hard to Tell Apart
Jan Rozman, Sumesh P. Thampi, Julia M. Yeomans
Active nematic models explain the topological defects and flow patterns observed in epithelial tissues, but the nature of active stress-whether it is extensile or contractile, a ke…
Junctional-Fluctuation-Mediated Fluidisation of Multi-Phase Field Epithelial Monolayers
James N. Graham, Jan Rozman
We analyse a multi-phase field model for an epithelial monolayer with pairwise adhesions between neighbouring cells following an Ornstein-Uhlenbeck process, representing the stocha…
Spontaneous Hole Formation in Cell Monolayers Emerges from Collective Cell Motion
Diogo E. P. Pinto, Jan Rozman, Julia M. Yeomans
Although cell monolayers typically remain confluent, they can spontaneously develop persistent holes as a result of collective cellular motion. Recent studies on MDCK monolayers cu…
Cell Sorting in an Active Nematic Vertex Model
Jan Rozman, Julia M. Yeomans
We study a mixture of extensile and contractile cells using a vertex model extended to include active nematic stresses. The two cell populations phase separate over time. While pha…
Cell-level modelling of homeostasis in confined epithelial monolayers
KVS Chaithanya, Jan Rozman, Andrej Košmrlj +1
Tissue homeostasis, the biological process of maintaining a steady state in tissue via control of cell proliferation, death, and metabolic function, is essential for the developmen…
Basolateral mechanics prevents rigidity transition in epithelial monolayers
Jan Rozman, Matej Krajnc, Primož Ziherl
The mechanics of epithelial tissues, which is governed by forces generated in various cell domains, is often investigated using two-dimensional models that account for the apically…
Vertex model with internal dissipation enables sustained flows
Jan Rozman, Chaithanya K. V. S., Julia M. Yeomans +1
Complex tissue flows in epithelia are driven by intra- and inter-cellular processes that generate, maintain, and coordinate mechanical forces. There has been growing evidence that…