1 citations · 2 across the 4 of their papers we have counts for
6 papers
An efficient and flexible generalization of transit compartment models for delayed biological processes
Giulia Belluccini, Christiaan H. van Dorp, Linjie Huang +3
Transit compartment models are widely used in pharmacokinetics/pharmacodynamics to represent delayed biological processes such as absorption, maturation, cellular proliferation, an…
Frequentist and Bayesian population pharmacometrics: similarities, differences, and practical implications
Jodie A. Cochrane, Haini Wen, Liang Yang +2
Although the frequentist versus Bayesian debate has a long-standing history, and both are well-established approaches for inference, they are often considered separately in pharmac…
Genuine and spurious bistability in a simple epidemic model with waning immunity
Francesca Scarabel, Harry Coldwell, Tyler Cassidy
We study an infection-age structured epidemic model in which both the infectivity and the rate of loss of immunity depend on the time-since-infection. The model can be equivalently…
A nonparametric approach to practical identifiability of nonlinear mixed effects models
Tyler Cassidy, Stuart T. Johnston, Michael Plank +4
Mathematical modelling is a widely used approach to understand and interpret clinical trial data. This modelling typically involves fitting mechanistic mathematical models to data…
Using multi-delay discrete delay differential equations to accurately simulate models with distributed delays
Tyler Cassidy
Delayed processes are ubiquitous throughout biology. These delays may arise through maturation processes or as the result of complex multi-step networks, and mathematical models wi…
Reducing phenotype-structured PDE models of cancer evolution to systems of ODEs: a generalised moment dynamics approach
Chiara Villa, Philip K Maini, Alexander P Browning +3
Intratumour phenotypic heterogeneity is nowadays understood to play a critical role in disease progression and treatment failure. Accordingly, there has been increasing interest in…