4 papers
Distinguishing case-mix from context heterogeneity in prognostic regression model synthesis settings
Max Behrens, Janis M. Nolde, Eleni Papakonstantinou +6
Prognostic regression models often synthesize data from multiple sites, whether within a multi-site study, across federated settings, or in individual participant data meta-analysi…
Assessing the Impact of Model Assumptions in Network Meta-Regression: A Simulation Study
Nana-adjoa Kwarteng, Guido Schwarzer, Adriani Nikolakopoulou +1
Network meta-regression (NMR) extends network meta-analysis (NMA) by synthesizing evidence on multiple treatments while adjusting for potential effect modifiers. By accounting for…
Producing treatment hierarchies in network meta-analysis using probabilistic models and treatment-choice criteria
Theodoros Evrenoglou, Adriani Nikolakopoulou, Guido Schwarzer +2
A key output of network meta-analysis (NMA) is the relative ranking of treatments; nevertheless, it has attracted substantial criticism. Existing ranking methods often lack clear i…
Meta-analysis models relaxing the random effects normality assumption: methodological systematic review and simulation study
Kanella Panagiotopoulou, Theodoros Evrenoglou, Christopher H Schmid +2
Random effects meta-analysis is widely used for synthesizing studies under the assumption that underlying effects come from a normal distribution. However, under certain conditions…