3 papers
q-bio.QM2026
scpFormer: A Foundation Model for Unified Representation and Integration of the Single-Cell Proteomics
Qifeng Zhou, Lei Yu, Yuzhi Guo +5
The integration of single-cell proteomic data is often hindered by the fragmented nature of targeted antibody panels. To address this limitation, we introduce scpFormer, a transfor…
cs.LG2025
GenePheno: Interpretable Gene Knockout-Induced Phenotype Abnormality Prediction from Gene Sequences
Jingquan Yan, Yuwei Miao, Lei Yu +4
Exploring how genetic sequences shape phenotypes is a fundamental challenge in biology and a key step toward scalable, hypothesis-driven experimentation. The task is complicated by…
q-bio.QM2024
ALPHAGMUT: A Rationale-Guided Alpha Shape Graph Neural Network to Evaluate Mutation Effects
Boshen Wang, Bowei Ye, Lin Xu +1
In silico methods evaluating the mutation effects of missense mutations are providing an important approach for understanding mutations in personal genomes and identifying disease-…