activity
20212025
most citedA perspective on the current state-of-the-art of quantum computing for drug discovery applications

190 citations · 220 across the 9 of their papers we have counts for

collaborators

9 papers

quant-ph2025

Optimizing two-dimensional isometric tensor networks with quantum computers

Sebastian Leontica, Alberto Baiardi, Julian Schuhmacher +2

We propose a hybrid quantum-classical algorithm for approximating the ground state of two-dimensional quantum systems using an isometric tensor network ansatz, which maps naturally…

quant-ph2025

An unbiased measure over the matrix product state manifold

Sebastian Leontica, Andrew G. Green

Matrix product states are useful representations for a large variety of naturally occurring quantum states. Studying their typical properties is important for understanding univers…

quant-ph2024

Zero-point energy of tensor fluctuations on the MPS manifold

Sebastian Leontica, Andrew G. Green

This work presents a method for studying low-energy physics in highly correlated magnetic systems using the matrix product state (MPS) manifold. We adapt the spin-wave approach, wh…

quant-ph2024

Entanglement growth from squeezing on the MPS manifold

Sebastian Leontica, Andrew G. Green

Finding suitable characterizations of quantum chaos is a major challenge in many-body physics, with a central difficulty posed by the linearity of the Schrödinger equation. A possi…

quant-ph2023★ 3 cited

Purification Dynamics in a Continuous-time Hybrid Quantum Circuit Model

Sebastian Leontica, Max McGinley

We introduce a continuous time model of many-body quantum dynamics based on infinitesimal random unitary operations, combined with projective measurements. We consider purification…

quant-ph2022★ 8 cited

Exploring the neighborhood of 1-layer QAOA with Instantaneous Quantum Polynomial circuits

Sebastian Leontica, David Amaro

We embed 1-layer QAOA circuits into the larger class of parameterized Instantaneous Quantum Polynomial circuits to produce an improved variational quantum algorithm for solving com…

physics.chem-ph2022★ 190 cited

A perspective on the current state-of-the-art of quantum computing for drug discovery applications

Nick S. Blunt, Joan Camps, Ophelia Crawford +9

Computational chemistry is an essential tool in the pharmaceutical industry. Quantum computing is a fast evolving technology that promises to completely shift the computational cap…

quant-ph2022★ 19 cited

Quantifying information scrambling via Classical Shadow Tomography on Programmable Quantum Simulators

Max McGinley, Sebastian Leontica, Samuel J. Garratt +2

We develop techniques to probe the dynamics of quantum information, and implement them experimentally on an IBM superconducting quantum processor. Our protocols adapt shadow tomogr…

quant-ph2021

Schrödinger cat states of a macroscopic charged particle co-trapped with an ion

Sebastian Leontica, Christopher Foot

We investigate the feasibility of observing matter-wave interference of a micron-sized charged particle by putting it into a quantum superposition of states with a distinguishable…