3 papers
q-bio.BM2025
Structural Flexibility of the TCF7L2-DNA Complex with the Type 2 Diabetes SNP rs7903146
Karthik Venuturimilli, Yang Ha
The single nucleotide polymorphism (SNP) rs7903146 in the TCF7L2 gene has been determined as one of the strongest common genetic risk factors for Type 2 Diabetes (T2D). The locatio…
q-bio.QM2023
Predicting Drug Solubility Using Different Machine Learning Methods -- Linear Regression Model with Extracted Chemical Features vs Graph Convolutional Neural Network
John Ho, Zhao-Heng Yin, Colin Zhang +2
Predicting the solubility of given molecules remains crucial in the pharmaceutical industry. In this study, we revisited this extensively studied topic, leveraging the capabilities…
cs.LG2023
Developing novel ligands with enhanced binding affinity for the sphingosine 1-phosphate receptor 1 using machine learning
Colin Zhang, Yang Ha
Multiple sclerosis (MS) is a debilitating neurological disease affecting nearly one million people in the United States. Sphingosine-1-phosphate receptor 1, or S1PR1, is a protein…