3 papers
q-bio.GN2025
MergeDNA: Context-aware Genome Modeling with Dynamic Tokenization through Token Merging
Siyuan Li, Kai Yu, Anna Wang +7
Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit.…
q-bio.GN2025
EnTao-GPM: DNA Foundation Model for Predicting the Germline Pathogenic Mutations
Zekai Lin, Haoran Sun, Yucheng Guo +8
Distinguishing pathogenic mutations from benign polymorphisms remains a critical challenge in precision medicine. EnTao-GPM, developed by Fudan University and BioMap, addresses thi…
cs.LG2025
Life-Code: Central Dogma Modeling with Multi-Omics Sequence Unification
Zicheng Liu, Siyuan Li, Zhiyuan Chen +6
The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. Although modern biological pre-tr…