3 papers
stat.ME2026
Efficient estimation of cumulative incidence curves via data fusion with surrogates: application to integrated analysis of vaccine trial and immunobridging data
Pan Zhao, Peter B. Gilbert, Oliver Dukes +1
Refined vaccine regimens containing variant-matched inserts are often authorized based on historical phase 3 efficacy trials together with immunobridging studies. Phase 3 trials ar…
stat.ME2026
Dealing with positivity violations in mediation analysis via weighted controlled effects, with application to assessing immune correlates of protection in antigen-experienced participants
Qijia He, Bo Zhang
Causal mediation analysis has become an important and increasingly used framework for evaluating candidate immune response biomarkers in vaccine research. A controlled effects appr…
stat.ME2025
Debiasing hazard-based, time-varying vaccine effects using vaccine-irrelevant infections: An observational extension of a pivotal Phase 3 COVID-19 vaccine efficacy trial
Ethan Ashby, Dean Follmann, Holly Janes +5
Understanding how vaccine effectiveness (VE) changes over time can provide evidence-based guidance for public health decision making. While commonly reported by practitioners, time…