4 papers
Towards Integrated Clinical-Computational Nuclear Medicine
Faraz Farhadi, Shadi A. Esfahani, Fereshteh Yousefirizi +7
The field of Clinical-Computational Nuclear Medicine is rapidly advancing, fueled by AI, tracer kinetic modeling, radiomics, and integrated informatics. These technologies improve…
Mathematical and Computational Nuclear Oncology: Toward Optimized Radiopharmaceutical Therapy via Digital Twins
Marc Ryhiner, Yangmeihui Song, Babak Saboury +3
This article presents the general framework of theranostic digital twins (TDTs) in computational nuclear medicine, designed to support clinical decision-making and improve cancer p…
An Overview of Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Models
Deni Hardiansyah, Bisma Baron Patrianesha, Kuangyu Shi +3
This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical…
Quantitative and Computational Radiobiology for Precision Radiopharmaceutical Therapies
Tahir Yusufaly, Hamid Abdollahi, Babak Saboury +1
This article reviews the evolving field of radiobiology, emphasizing the need for advanced multiscale, mechanistic models to optimize radiopharmaceutical therapies (RPT). While the…