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q-bio.BM2026
In Vivo Length Distributions as Mechanistic Fingerprints of Pathological Protein Aggregation
Matthew W. Cotton, David Klenerman, Georg Meisl
Modern imaging techniques can resolve individual pathological protein aggregates in postmortem human samples, providing detailed measurements of aggregate size distributions that a…
q-bio.BM2025
A universal phase-plane model for in vivo protein aggregation
Matthew W. Cotton, Alain Goriely, David Klenerman +1
Neurodegenerative diseases are driven by the accumulation of protein aggregates in the brain of affected individuals. The aggregation behaviour in vitro is well understood and driv…