5 papers
In Vivo Length Distributions as Mechanistic Fingerprints of Pathological Protein Aggregation
Matthew W. Cotton, David Klenerman, Georg Meisl
Modern imaging techniques can resolve individual pathological protein aggregates in postmortem human samples, providing detailed measurements of aggregate size distributions that a…
A universal phase-plane model for in vivo protein aggregation
Matthew W. Cotton, Alain Goriely, David Klenerman +1
Neurodegenerative diseases are driven by the accumulation of protein aggregates in the brain of affected individuals. The aggregation behaviour in vitro is well understood and driv…
A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease
Shih-Huan Huang, Matthew W. Cotton, Tuomas P. J. Knowles +2
A central challenge in modeling neurodegenerative diseases is connecting cellular-level mechanisms to tissue-level pathology, in particular to determine whether pathology is driven…
Hubble's Multi-Year Search for Exospheres in the TRAPPIST-1 System Reveals Frequent Microflares
David Berardo, Julien de Wit, Michael Gillon +14
Ly- observations provide a powerful probe of stellar activity and atmospheric escape in exoplanetary systems. We present here an analysis of 104 HST/STIS orbits monitoring the T…
Catalysis-Induced Phase Separation and Autoregulation of Enzymatic Activity
Matthew W. Cotton, Ramin Golestanian, Jaime Agudo-Canalejo
We present a thermodynamically consistent model describing the dynamics of a multi-component mixture where one enzyme component catalyzes a reaction between other components. We fi…