4 papers
Swarms of Large Language Model Agents for Protein Sequence Design with Experimental Validation
Fiona Y. Wang, Di Sheng Lee, David L. Kaplan +1
Designing proteins de novo with tailored structural, physicochemical, and functional properties remains a grand challenge in biotechnology, medicine, and materials science, due to…
Artificial Intelligence for Food Innovation
Bianca Datta, Markus J. Buehler, Yvonne Chow +14
Global food systems must deliver nutritious, sustainable foods while sharply reducing environmental impact. Yet, food innovation remains slow, empirical, and fragmented. Artificial…
ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a protein language diffusion model
Bo Ni, David L. Kaplan, Markus J. Buehler
Through evolution, nature has presented a set of remarkable protein materials, including elastins, silks, keratins and collagens with superior mechanical performances that play cru…
Generative modeling, design and analysis of spider silk protein sequences for enhanced mechanical properties
Wei Lu, David L. Kaplan, Markus J. Buehler
Spider silks are remarkable materials characterized by superb mechanical properties such as strength, extensibility and lightweightedness. Yet, to date, limited models are availabl…