2 papers
q-bio.MN2025
Comment on "Direct Targeting and Regulation of RNA Polymerase II by Cell Signaling Kinases"
Jia Li, Shu-Feng Zhou
Dabas et al. in Science 2025 report that approximately 117 human kinases directly phosphorylate the C-terminal domain (CTD) of RNA polymerase II (Pol II), proposing an extensive, d…
q-bio.CB2025
Comment on "Repair of DNA Double-Strand Breaks Leaves Heritable Impairment to Genome Function"
Yi Wang, Shu-Feng Zhou
Bantele and colleagues recently reported that repair of a single CRISPR/Cas9-induced DNA double-strand break (DSB) in the c-MYC topologically associated domain leads to a persisten…