3 papers
q-bio.QM2025
HyperADRs: A Hierarchical Hypergraph Framework for Drug-Gene-ADR Prediction
Ze Cai, Haotian Tang, Shuai Gao +3
Adverse drug reactions (ADRs) are a major barrier to safe and effective pharmacotherapy and increasingly reflect higher order interactions between drugs, genetic background, and cl…
q-bio.QM2025
SynCell: Contextualized Drug Synergy Prediction
Keqin Peng, Guangxin Su, Qinshan Shi +4
Drug synergy is profoundly influenced by cellular context, as variations in protein interaction landscapes and pathway activities across cell types reshape how drugs act in combina…
cs.CE2024
Heterogeneous Entity Representation for Medicinal Synergy Prediction
Jiawei Wu, Jun Wen, Mingyuan Yan +4
Medicinal synergy prediction is a powerful tool in drug discovery and development that harnesses the principles of combination therapy to enhance therapeutic outcomes by improving…