8 papers
MemNovo: Look Back at the Spectrum for Balanced De Novo Peptide Sequencing from Mass Spectrometry
Dongxin Lyu, Jingbo Zhou, Hongxin Xiang +2
De novo peptide sequencing from tandem mass spectrometry is pivotal in proteomics, enabling identification of novel peptides without reference databases. While recent Transformer-b…
scTranslation: A Comprehensive Benchmark for Single-Cell Multi-Omics Modality Translation
Jiabei Cheng, Jingbo Zhou, Jun Xia +4
Simultaneous measurement of multiple omics modalities in single cells enables researchers to gain a more comprehensive understanding of cellular states and regulatory mechanisms. H…
Doloris: Dual Conditional Diffusion Implicit Bridges with Sparsity Masking Strategy for Unpaired Single-Cell Perturbation Estimation
Changxi Chi, Jun Xia, Yufei Huang +9
Estimating single-cell responses across various perturbations facilitates the identification of key genes and enhances drug screening, significantly boosting experimental efficienc…
Regressor-guided Diffusion Model for De Novo Peptide Sequencing with Explicit Mass Control
Shaorong Chen, Jingbo Zhou, Jun Xia
The discovery of novel proteins relies on sensitive protein identification, for which de novo peptide sequencing (DNPS) from mass spectra is a crucial approach. While deep learning…
VecFormer: Towards Efficient and Generalizable Graph Transformer with Graph Token Attention
Jingbo Zhou, Jun Xia, Siyuan Li +11
Graph Transformer has demonstrated impressive capabilities in the field of graph representation learning. However, existing approaches face two critical challenges: (1) most models…
Departures: Distributional Transport for Single-Cell Perturbation Prediction with Neural Schrödinger Bridges
Changxi Chi, Yufei Huang, Jun Xia +4
Predicting single-cell perturbation outcomes directly advances gene function analysis and facilitates drug candidate selection, making it a key driver of both basic and translation…