3 citations · 3 across the 4 of their papers we have counts for
4 papers
Exhausting the type I error level in event-driven group-sequential designs with a closed testing procedure for progression-free and overall survival
Moritz Fabian Danzer, Kaspar Rufibach, Jan Beyersmann +1
In oncological clinical trials, overall survival (OS) is the gold-standard endpoint, but long follow-up and treatment switching can delay or dilute detectable effects. Progression-…
Correcting for sampling variability in maximum likelihood-based one-sample log-rank tests
Moritz Fabian Danzer, Rene Schmidt
Single-arm studies in the early development phases of new treatments are not uncommon in the context of rare diseases or in paediatrics. If an assessment of efficacy is to be made…
Confirmatory Adaptive Hypothesis Tests in Markovian Illness-Death Models
Rene Schmidt, Moritz Fabian Danzer
Classic adaptive designs for time-to-event trials are based on the log-rank statistic and its increments. Thereby, only information from the time-to-event endpoint on which the sel…
Confirmatory adaptive group sequential designs for clinical trials with multiple time-to-event outcomes in Markov models
Moritz Fabian Danzer, Andreas Faldum, Thorsten Simon +2
The analysis of multiple time-to-event outcomes in a randomised controlled clinical trial can be accomplished with exisiting methods. However, depending on the characteristics of t…