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physics.bio-ph2025
Binding Kinetics Oppositely Regulates type II Topoisomerase Relaxation and Decatenation Activities
Cleis Battaglia, Filippo Conforto, Yair Augusto Gutierrez Fosado +4
Type II Topoisomerases (topo II) are critical to simplify genome topology during transcription and replication. They identify topological problems and resolve them by passing a dou…
cond-mat.soft2025
Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA
Filippo Conforto, Antonio Valdes, Willem Vanderlinden +1
Structural-Maintenance-of-Chromosome (SMC) complexes such as condensins organise the folding of chromosomes. However, their role in modulating the entanglement of DNA and chromatin…