3 papers
physics.bio-ph2025
Binding Kinetics Oppositely Regulates type II Topoisomerase Relaxation and Decatenation Activities
Cleis Battaglia, Filippo Conforto, Yair Augusto Gutierrez Fosado +4
Type II Topoisomerases (topo II) are critical to simplify genome topology during transcription and replication. They identify topological problems and resolve them by passing a dou…
physics.bio-ph2024
Bridging-Induced Phase Separation and Loop Extrusion Drive Noise in Chromatin Transcription
Michael Chiang, Cleis Battaglia, Giada Forte +3
Transcriptional noise, or heterogeneity, is important in cellular development and in disease. The molecular mechanisms driving it are, however, elusive and ill-understood. Here, we…
cond-mat.soft2023
Loops are Geometric Catalysts for DNA Integration
Cleis Battaglia, Davide Michieletto
The insertion of HIV and other DNA elements within genomes underpins both genetic diversity and disease when unregulated. Most of these insertions are not random and occupy specifi…