11 papers
AQP4 Regulates Gap-Dominated Glymphatic Clearance through Dynamic Gliovascular Coupling
Tanran Zhang, Huaxiong Huang, Robert Eisenberg +1
Aquaporin-4 (AQP4) is enriched at perivascular astrocytic endfeet, and impaired AQP4 function or localization is associated with reduced glymphatic transport. However, mechanical m…
TWLR: Text-Guided Weakly-Supervised Lesion Localization and Severity Regression for Explainable Diabetic Retinopathy Grading
Xi Luo, Shixin Xu, Ying Xie +4
Accurate medical image analysis can greatly assist clinical diagnosis, but its effectiveness relies on high-quality expert annotations Obtaining pixel-level labels for medical imag…
A novel multiscale modelling for the hemodynamics in retinal microcirculation with an analytic solution for the capillary-tissue coupled system
Chang Lin, Zilong Song, Robert Eisenberg +2
Mathematical modelling of the microcirculatory hemodynamics in the retina is an essential tool for understanding various diseases of the retina, yet remains challenging due to the…
Glymphatic Clearance in the Optic Nerve: A Multidomain Electro-osmostic Model
Shanfeng Xiao, Huaxiong Huang, Robert Eisenberg +2
Effective metabolic waste clearance and maintaining ionic homeostasis are essential for the health and normal function of the central nervous system. To understand its mechanism an…
Pump-driven droplet electrohydrodynamics: deformation, pinch-off and recoalescence
Yuzhe Qin, Huaxiong Huang, Zilong Song +1
We investigate pump-driven droplet electrohydrodynamics with an emphasis on deformation, pinch-off, and recoalescence. A thermodynamically consistent phase-field framework is devel…
Proper Orthogonal Decomposition-based Model-Order Reduction for Smoothed Particle Hydrodynamics Simulation -- Mass-Spring-Damper System
Lidong Fang, Zilong Song, Kirk Fraser +1
Model Order Reduction (MOR) based on Proper Orthogonal Decomposition (POD) and Smooth Particle Hydrodynamics (SPH) has proven effective in various applications. Most MOR methods ut…
Proper Orthogonal Decomposition-based Model-Order Reduction for Smoothed Particle Hydrodynamics Simulation
Lidong Fang, Zilong Song, Kirk Fraser +3
In this paper, we present a projection-based model-order reduction (MOR) technique for smoothed particle hydrodynamics (SPH) simulations, which is a mesh-free approach within the L…
Micro-Macro Modeling of Polymeric Fluids with Multi-Bead Polymer Chain
Xuelian Bao, Lidong Fang, Huaxiong Huang +2
This work extends the classical dumbbell (two-bead) model of polymer chains to a more detailed multi-bead representation, where each polymer chain consists of beads connected b…
A thermodynamically consistent phase-field model for mass transport with interfacial reaction and deformation
Zhaoyang Wang, Huaxiong Huang, Ping Lin +1
In this paper, a thermodynamically consistent phase-field model is proposed to describe the mass transport and reaction processes of multiple species in a fluid. A key feature of t…
Multidomain Model for Optic Nerve Potassium Clearance: Roles of Glial Cells and Perivascular Spaces
Shanfeng Xiao, Huaxiong Huang, Robert Eisenberg +2
The accumulation of potassium in the extracellular space surrounding nerve cells is a fundamental aspect of biophysics that has garnered significant attention in recent research. T…
A multi-domain model for microcirculation in optic nerve: blood flow and oxygen transport
Zilong Song, Shixin Xu, Robert Eisenberg +1
Microcirculation of blood and oxygen transport play important roles in biological function of optic nerve and are directly affected by damages or pathologies. This work develops a…