3 papers
q-bio.QM2026
OCOO-T : A Simple and Scalable Virtual Cell Model for Transcriptional Perturbation Response Prediction
Danning Jiang, Zheming An, Zhiwen Yan +3
Predicting single-cell transcriptional responses to genetic, chemical and cytokine perturbations is a fundamental challenge in computational biology and AI Virtual Cell (AIVC) mode…
q-bio.GN2025
siDPT: siRNA Efficacy Prediction via Debiased Preference-Pair Transformer
Honggen Zhang, Xiangrui Gao, Lipeng Lai
Small interfering RNA (siRNA) is a short double-stranded RNA molecule (about 21-23 nucleotides) with the potential to cure diseases by silencing the function of target genes. Due t…
q-bio.QM2024
mRNA2vec: mRNA Embedding with Language Model in the 5'UTR-CDS for mRNA Design
Honggen Zhang, Xiangrui Gao, June Zhang +1
Messenger RNA (mRNA)-based vaccines are accelerating the discovery of new drugs and revolutionizing the pharmaceutical industry. However, selecting particular mRNA sequences for va…