2 papers
q-bio.QM2026
EasyNano: rapid epitope-targeted nanobody CDR design via differentiable distogram optimization with ESMFold2
Yue Hu, Wanyu Cheng, Junqing Wang +1
Computational design of nanobodies that bind user-specified protein epitopes could transform therapeutic development, but current methods either rely on stochastic sampling requiri…
q-bio.QM2026
Interpretable enzyme function prediction via sparse autoencoder features of ESMC across the microbial protein universe
Yue Hu, Wanyu Cheng, Junqing Wang +1
Microbial genomes and metagenomes contain millions of proteins whose enzymatic functions remain unknown, the enzyme dark matter. While deep learning has improved protein function p…