4 papers
PDA in Action: Ten Principles for High-Quality Multi-Site Clinical Evidence Generation
Yong Chen, Jiayi Tong, Yiwen Lu +13
Background: Distributed Research Networks (DRNs) offer significant opportunities for collaborative multi-site research and have significantly advanced healthcare research based on…
Validity in machine learning for extreme event attribution
Cassandra C. Chou, Scott L. Zeger, Benjamin Q. Huynh
Extreme event attribution (EEA), which assesses the extent to which disasters are caused by climate change, is crucial for informing climate policy and legal proceedings. Machine l…
Probabilistic Clustering using Shared Latent Variable Model for Assessing Alzheimers Disease Biomarkers
Yizhen Xu, Scott Zeger, Zheyu Wang
The preclinical stage of many neurodegenerative diseases can span decades before symptoms become apparent. Understanding the sequence of preclinical biomarker changes provides a cr…
A Bayesian Hierarchical Model for Prediction of Latent Health States from Multiple Data Sources with Application to Active Surveillance of Prostate Cancer
R. Yates Coley, Aaron J. Fisher, Mufaddal Mamawala +3
In this article, we present a Bayesian hierarchical model for predicting a latent health state from longitudinal clinical measurements. Model development is motivated by the need t…